For the first time in the history of mankind, a team of United States of America Surgeons headed by Dr. Bartley Griffith, have successfully transplanted a genetically modified pig’s heart to replace the heart of a 57-year-old patient.
The historic surgical procedure took place at the University of Maryland Medical School, USA on Friday. In an eight-hour operation, the patient, David Bennett Sr. of Maryland, who had life-threatening heart disease received the transplant of genetically modified pig and was doing well.
It is the first successful transplant of a pig’s heart into a human being. “It creates the pulse, it creates the pressure, it is his heart,” said Dr. Bartley Griffith, the director of the cardiac transplant program at the medical center, who performed the operation.
The patient, David Bennett, had been deemed ineligible for human transplant — a decision that is often taken when the recipient has very poor underlying health.
He is now recovering and being carefully monitored to determine how the new organ performs.
“It was either die or do this transplant. I want to live. I know it’s a shot in the dark, but it’s my last choice,” the Maryland resident said a day before the surgery.
Dr. Bartley Griffith a Professor of Surgery has been practicing Cardiothoracic surgery for over 47 years after graduating Jefferson Medical College Of Thomas Jefferson University, Thomas Jefferson University in 1974.
He said: “It’s working and it looks normal. We are thrilled, but we don’t know what tomorrow will bring us. This has never been done before.”
“This was a breakthrough surgery and brings us one step closer to solving the organ shortage crisis,” said Bartley Griffith, who surgically transplanted the pig heart.
“We are proceeding cautiously, but we are also optimistic that this first-in-the-world surgery will provide an important new option for patients in the future.” he explained.
Bennett’s donor pig belonged to a herd that had undergone genetic editing procedures.
Three genes that would have led to the rejection of pig organs by humans were “knocked out,” as was a gene that would have led to excessive growth of pig heart tissue.
Six human genes responsible for human acceptance were inserted into the genome, for a total of 10 unique gene edits.
The editing was performed by Virginia-based biotech firm Revivicor, which also supplied the pig used in a breakthrough kidney transplant on a brain-dead patient in New York in October.
But while that surgery was purely a proof-of-concept experiment, and the kidney was connected outside the patient’s body, the new surgery is intended to save a person’s life.
The donated organ was kept in an organ-preservation machine ahead of the surgery, and the team also used an experimental new drug made by Kiniksa Pharmaceuticals along with conventional anti-rejection drugs to suppress the immune system.
About 110,000 Americans are currently waiting for an organ transplant, and more than 6,000 patients die each year before getting one, according to official figures.
To meet demand, doctors have long been interested in so-called xenotransplantation, or cross-species organ donation, with experiments tracing back to the 17th century.
Early research focused on harvesting organs from primates — for example, a baboon heart was transplanted into a newborn known as “Baby Fae” in 1984, but she survived only 20 days.
Today, pig heart valves are widely used in humans, and pigskin is grafted on human burn victims.
Pigs make the ideal donors because of their size, their rapid growth and large litters, and the fact they are already raised as a food source.